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BOOIJ , Linda  PhD
 
 
     
 
Research Axis
  
   
 
 
 
Research Theme
  
   
 
 
 
Address
  
 
CHU Sainte-Justine
 
 
3175 Chemin de la Côte Sainte-Catherine
  
 
Montréal  (QC), Canada
  
 
H3T 1C5
 
     
 
Phone
  
 
514 345-4931 #4041
 
 
 
 
Fax
  
 
514 345-2176
 
     
     
     

linda.booij@umontreal.ca
 
 
Career Summary, Research Topics and Interests
 

TITLE

  • Assistant research professor, Department of Psychiatry, University of Montreal.
  • Adjunct Assistant professor, Department of Psychiatry, McGill University.

PROFESSIONAL EXPERIENCE

  • Visiting Professor, INScer (Brain Institute), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil, March 2012.
  • Assistant Professor, Dept. Of Clinical and Health Psychology, 2007-2008 (part-time).

EDUCATION

  • Postdoctoral research fellow, Department of Psychiatry, McGill University, Montreal, 2005-2009.
  • Ph.D. in Clinical Psychology, University of Leiden, the Netherlands, 2001-2005.
  • Masters in Research Methodology and Statistics, University of Leiden, 1996-2001.
  • Masters in Clinical Psychology, University of Leiden, 1997-2000.

RESEARCH TOPICS AND INTERESTS

My research program is about the neurobiological mechanisms of psychopathology. My current research examines the impact of early adversity and serotonergic genes on the development of the serotonin system, functioning of the frontal-limbic neural circuitry and risk for mental disorders (in particular, mood and impulse control disorders).

My other research interests involve the role of serotonin in emotional processing and in cognitive vulnerability to depression. The methods I use in my research program are a combination of epidemiology and experimental research and include neuroimaging (fMRI/PET), genetics, epigenetics and behavioural/cognitive measures.

MOST IMPORTANT RECENT PUBLICATIONS

  • Booij, L., Turecki, G., Leyton, M., Gravel, P., Lopez De Lara, C., Diksic, M. & Benkelfat, C. (2012). Polymorphic Variants in the TPH2 Gene Predict Brain Serotonin Synthesis in Humans. Molecular Psychiatry, Jul 12. doi: 10.1038/mp.2011.79. [Epub ahead of print].
  • Booij, L., Benkelfat, C., Leyton, M., Vitaro, F., Gravel, P., Levesque, M.L., Arseneault, L., Diksic, M., Tremblay, R.E. (2012). Perinatal effects on in vivo measures of brain serotonin synthesis in adulthood: a 27 year longitudinal study. European Neuropsychopharmacology, Jan 16. [Epub ahead of print]
  • Booij, L., Tremblay, R.E., Leyton, M., Seguin, J.R., Vitaro, F., Gravel, P., Perreau-Linck, E., Levesque, M., Durand, F., Diksic, M., Turecki, G., & Benkelfat, C. (2010). Brain serotonin synthesis in adult males characterized by physical aggression at school age: A 21 year longitudinal study. PLoSONE, 5(6):e11255.
  • Caramaschi, D., Booij, L., Petitclerc A., Boivin, M., Tremblay, R.E. (2012). Genetic and environmental contributions to saliva testosterone levels in male and female infant twins.Psychoneuroendocrinology, in press.
  • Lévesque M.L., Beauregard M., Fortier E., Tremblay R.E., Brendgen M., Pérusse D., Dionne G., Robaey P., Vitaro F., Boivin M., Booij L. (2011). Altered patterns of fronto-limbic activation in children with familial risk of depression. Journal of Affective disorders, 135, 410-413.

RECENT PRESENTATIONS

  • Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil, March 27 2012. The impact of the early environment on brain, behavior and cognitive processes: Evidence from longitudinal cohort studies.
  • Sainte-Justine Hospital Research Centre, University of Montreal, February 14 2012, Retreat, research axis Fetomaternal and Neonatal Pathologies and Metabolic Health, Cohortes et analyses épigénétiques.
  • 34th Annual Canadian College of Neuropsychopharmacology (CCNP) Meeting, Montreal, May 21-23 2011. Early environmental influences on the serotonin system: potential mechanisms and consequences for emotion regulation.
  • 21st biennial conference of the International Society of Social and Behavioral Development (ISSBD), Lusaka, Zambia, July 2010. Brain serotonin synthesis in adult males characterized by physical aggression at school age: A 21 year longitudinal study.
  • University of Amsterdam, Department of Psychology, October 2010. The neurobiology of depression.
 
Awards and Distinctions
 
  • Marie Gaumond award for young researchers working on affective disorders, 2011.
  • Fonds de recherche du Québec-Santé, Research Scholar career award, junior 1, 2011-2015
  • Fonds de recherche du Québec-Santé, Établissement des jeunes chercheurs, 2011 2014.
  • Operating grant Canadian Institutes of Health Research (CIHR), 2010-2015.
  • Research grant from the H.F. Guggenheim Foundation, 2010-2011.
  • Research grant, Quebec Brain Imaging Network-Pilot project competition, 2010.
  • Postdoctoral Fellowship, Fonds de la recherche en santé du Québec, 2007-2009.
  • Research grant, Netherlands Organisation for Scientific Research, 2007-2008.
  • Postdoctoral Fellowship, McGill University Health Centre, 2005 and 2007.
  • Quebec merit postdoctoral fellowship for foreign students, Fonds Québécois de recherche sur la nature et les technologies, 2006-2007.
  • Research Stipend (NWO-Talent), Netherlands Organisation for Scientific Research, 2005.
 
Most Important Publications Selected by the Researcher
 
Booij L, Benkelfat C, Leyton M, Vitaro F, Gravel P, Lévesque M, Arseneault L, Diksic M, Tremblay RE,
Perinatal effects on in vivo measures of brain serotonin synthesis in adulthood: a 27 year longitudinal study
Eur Neuropsychopharmacol 2012  419-423.		  
   
Lévesque M, Beauregard M, Ottenhof KW, Fortier E, Tremblay RE, Brendgen M, Pérusse D, Dionne G, Robaey P, Vitaro F, Boivin M, Booij L,
Altered patterns of brain activity during transient sadness in children at familial risk for major depression
J Affect Disord 2011  410-413.		  
   
Booij L, Turecki G, Leyton M, Gravel P, Lopez de Lara C, Diksic M, Benkelfat C,
Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans
Mol Psychiatry 2012  809-817.		  
   
van Steenbergen H, Booij L, Band GP, Hommel B, Van der Does AJW,
Affective regulation of cognitive-control adjustments in remitted depressive patients after acute tryptophan depletion
Cogn Affect Behav Neurosc 2012  280-286.		  
   
Wang D, Szyf M, Benkelfat C, Provençal N, Turecki G, Caramaschi D, Côté S, Vitaro F, Tremblay RE, Booij L,
Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression
PLoS ONE 2012  e39501.		  
   
Publications reported to FRSQ
 
 
 
 

Awards and distinctions

Awards and Distinctions

Dr. Sylvie Lemay, honor graduate at the 25th anniversary of her graduation class at the University of Montreal
July 2012 – Dr. Lemay was among eight of the 8,000 graduates of the class of 1987 whose career and achievements were highlighted.

Dr. Philip Awadalla receives the 2012 CSCI Joe Doupe Young Investigator Award
August 2012 – The award was given to Dr. Awadalla by the Canadian Society for Clinical Investigation for having accomplished a significant and innovative piece of work within eight years of his first academic appointment.

Dr. William Fraser receives the 2012 CSCI Distinguished Scientist Award
August 2012 – The award was given to Dr. Fraser by the Canadian Society for Clinical Investigation in recognition of his outstanding contribution to pushing back the frontiers of knowledge and the esteem he enjoys in his field as an expert, innovator and leading investigator as a Canadian MD or PhD medical scientist.

Dr. Guy Rouleau is awarded the Margolese National Brain Prize.

Dr. Luis Barreiro has received the «Career Development Award 2012» from the Human Frontiers Science Program (HFSP) for his study : Deciphering the genetic architecture of immune responses to infection.

Dr. Francine Ducharme has received The Career Research Award for excellence in Canadian child and youth research from the Canadian Paediatric Society (www.cps.ca) 2012.

Three awards from the Foundation of Stars at the Research Centre of CHU Sainte-Justine. The "Young Researcher Award" was awarded to Dr. Elie Haddad, MD, PhD October 13, 2011.

Nomination of Dr. Emile Levy at the Canadian Academy of Health Sciences (CAHS) September 15, 2011.

Dr. Guy Rouleau was awarded the Biotechnologie de demain 2011 award by Genome Québec on June 21, 2011.

Dr. Francine Ducharme wins Award IMS Brogan April 14, 2011.

Dr. Hubert Labelle wins the application of knowledge of our research ambassadors of IMHA (Institute of Musculoskeletal Health and Arthritis) Institutes of Health Research Canada.

Dr. Catherine Herba wins Award Monique-Gaumont for young researchers working on the theme of depression.

Dr. Anne Monique Nuyt wins Award of Excellence Distinction Desjardins Financial Security, the Canada Foundation for heart disease 2010-2011.

The Premier of Québec honors new recipients of the National Order of Québec 2010 - Dr. Jean-Claude Fouron and Dr. Richard E Tremblay were nominated: Grade officers.
News

News

Postdoctoral scholarship recipients honored in the presence of diplomats from Asia, Europe and America at the Sainte-Justine University Hospital

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