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BOOIJ , Linda  PhD
Research Axis
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CHU Sainte-Justine
3175 Chemin de la Côte Sainte-Catherine
Montréal  (QC), Canada
H3T 1C5
514 345-4931 #4041
514 345-2176
Career Summary, Research Topics and Interests


  • Assistant research professor, Department of Psychiatry, University of Montreal.
  • Adjunct Assistant professor, Department of Psychiatry, McGill University.


  • Visiting Professor, INScer (Brain Institute), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil, March 2012.
  • Assistant Professor, Dept. Of Clinical and Health Psychology, 2007-2008 (part-time).


  • Postdoctoral research fellow, Department of Psychiatry, McGill University, Montreal, 2005-2009.
  • Ph.D. in Clinical Psychology, University of Leiden, the Netherlands, 2001-2005.
  • Masters in Research Methodology and Statistics, University of Leiden, 1996-2001.
  • Masters in Clinical Psychology, University of Leiden, 1997-2000.


My research program is about the neurobiological mechanisms of psychopathology. My current research examines the impact of early adversity and serotonergic genes on the development of the serotonin system, functioning of the frontal-limbic neural circuitry and risk for mental disorders (in particular, mood and impulse control disorders).

My other research interests involve the role of serotonin in emotional processing and in cognitive vulnerability to depression. The methods I use in my research program are a combination of epidemiology and experimental research and include neuroimaging (fMRI/PET), genetics, epigenetics and behavioural/cognitive measures.


  • Booij, L., Turecki, G., Leyton, M., Gravel, P., Lopez De Lara, C., Diksic, M. & Benkelfat, C. (2012). Polymorphic Variants in the TPH2 Gene Predict Brain Serotonin Synthesis in Humans. Molecular Psychiatry, Jul 12. doi: 10.1038/mp.2011.79. [Epub ahead of print].
  • Booij, L., Benkelfat, C., Leyton, M., Vitaro, F., Gravel, P., Levesque, M.L., Arseneault, L., Diksic, M., Tremblay, R.E. (2012). Perinatal effects on in vivo measures of brain serotonin synthesis in adulthood: a 27 year longitudinal study. European Neuropsychopharmacology, Jan 16. [Epub ahead of print]
  • Booij, L., Tremblay, R.E., Leyton, M., Seguin, J.R., Vitaro, F., Gravel, P., Perreau-Linck, E., Levesque, M., Durand, F., Diksic, M., Turecki, G., & Benkelfat, C. (2010). Brain serotonin synthesis in adult males characterized by physical aggression at school age: A 21 year longitudinal study. PLoSONE, 5(6):e11255.
  • Caramaschi, D., Booij, L., Petitclerc A., Boivin, M., Tremblay, R.E. (2012). Genetic and environmental contributions to saliva testosterone levels in male and female infant twins.Psychoneuroendocrinology, in press.
  • Lévesque M.L., Beauregard M., Fortier E., Tremblay R.E., Brendgen M., Pérusse D., Dionne G., Robaey P., Vitaro F., Boivin M., Booij L. (2011). Altered patterns of fronto-limbic activation in children with familial risk of depression. Journal of Affective disorders, 135, 410-413.


  • Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil, March 27 2012. The impact of the early environment on brain, behavior and cognitive processes: Evidence from longitudinal cohort studies.
  • Sainte-Justine Hospital Research Centre, University of Montreal, February 14 2012, Retreat, research axis Fetomaternal and Neonatal Pathologies and Metabolic Health, Cohortes et analyses épigénétiques.
  • 34th Annual Canadian College of Neuropsychopharmacology (CCNP) Meeting, Montreal, May 21-23 2011. Early environmental influences on the serotonin system: potential mechanisms and consequences for emotion regulation.
  • 21st biennial conference of the International Society of Social and Behavioral Development (ISSBD), Lusaka, Zambia, July 2010. Brain serotonin synthesis in adult males characterized by physical aggression at school age: A 21 year longitudinal study.
  • University of Amsterdam, Department of Psychology, October 2010. The neurobiology of depression.
Awards and Distinctions
  • Marie Gaumond award for young researchers working on affective disorders, 2011.
  • Fonds de recherche du Québec-Santé, Research Scholar career award, junior 1, 2011-2015
  • Fonds de recherche du Québec-Santé, Établissement des jeunes chercheurs, 2011 2014.
  • Operating grant Canadian Institutes of Health Research (CIHR), 2010-2015.
  • Research grant from the H.F. Guggenheim Foundation, 2010-2011.
  • Research grant, Quebec Brain Imaging Network-Pilot project competition, 2010.
  • Postdoctoral Fellowship, Fonds de la recherche en santé du Québec, 2007-2009.
  • Research grant, Netherlands Organisation for Scientific Research, 2007-2008.
  • Postdoctoral Fellowship, McGill University Health Centre, 2005 and 2007.
  • Quebec merit postdoctoral fellowship for foreign students, Fonds Québécois de recherche sur la nature et les technologies, 2006-2007.
  • Research Stipend (NWO-Talent), Netherlands Organisation for Scientific Research, 2005.
Most Important Publications Selected by the Researcher
Booij L, Benkelfat C, Leyton M, Vitaro F, Gravel P, Lévesque M, Arseneault L, Diksic M, Tremblay RE,
Perinatal effects on in vivo measures of brain serotonin synthesis in adulthood: a 27 year longitudinal study
Eur Neuropsychopharmacol 2012  419-423.
Lévesque M, Beauregard M, Ottenhof KW, Fortier E, Tremblay RE, Brendgen M, Pérusse D, Dionne G, Robaey P, Vitaro F, Boivin M, Booij L,
Altered patterns of brain activity during transient sadness in children at familial risk for major depression
J Affect Disord 2011  410-413.
Lataster J, Collip D, Ceccarini J, Hernaus D, Haas D, Booij L, van Os J, Pruessner J, Van Laere K, Myin-Germeys I,
Familial liability to psychosis is associated with attenuated dopamine stress signaling in ventromedial prefrontal cortex
Schizophr Bull 2014  66-77.
Nunes ML, Khan R, Gomes Filho I, Booij L, da Costa JC,
Maturational changes of neonatal electroencephalogram: A comparison between intra uterine and extra uterine development
Clin Neurophysiol 2014  (sous presse).
Booij L, Wang D, Lévesque M, Tremblay RE, Szyf M,
Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression
Philos Trans R Soc Lond B Biol Sci 2013  20120251.
Publications reported to FRSQ

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