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AWADALLA , Philip  PhD
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CHU Sainte-Justine
3175 Chemin de la Côte Sainte-Catherine
Montréal  (QC), Canada
H3T 1C5
514 345-4931 #3393
514 345-4731
Personal Website
Career Summary, Research Topics and Interests


  • Professor, Department of Pediatrics, University of Montreal, since 2007.
  • Director, CARTaGENE, since 2010.


  • Postdoctoral Fellow, University of California Davis, USA, 2001-2004.

  • Postdoctoral Fellow, University of British Columbia, Vancouver, 2000-2001.

  • PhD, University of Edinburgh, 1997-2000.

  • MSc, University of Toronto, 1994-1996.

Research Interests

  • Medical Population Genomics of Humans and Other Model Systems
    • Integrating development of next-generation applications for genome-wide sequencing of population data from humans and related pathogens with statistical methods. Goals are to identify key genomic regions associated with immunityt-related disease, adaptation and/or speciation. Understand basic deterministic and stochastic processes associated with variation in humans and in pediatric or neurologic disease cohorts.
  • Medical Genomic Epidemiology of Chronic Diseases
    • Large cohort studies of clinically relevant quantitative traits CARTaGENE. Systems biology approach to identifying critical genomic networks associated with chronic disease.
  • Computational genomics
    • Development of statistical models and computational approaches to making genomic inferences from population and comparative data. Emphasis is placed on probabilistic methods for inferring fitness consequences of mutations, demographic inferences, and gene mapping.
  • Evolutionary and Functional Genomics of Humans and Disease
    • Genome-wide resequencing, genotyping and expression assays from humans, humans infected with malaria, and malaria sampled globally with an emphasis on African and Asian populations. A population systems biology approach to identifying key genes and gene networks associated with infection and resistance in both the host and pathogen.


  • Human Frontiers in Science Program.
  • National Institutes of Health.
  • National Academies Keck Foundation for Innovation.
  • Canadian Foundation for Innovation.
  • Fonds de la recherche en santé du Québec (FRSQ).

Awards and Distinctions
  • 2012 Joe Doupe Young Investigator Award, Canadian Society for Clinical Investigation (CSCI) 2012
  • Genome Quebec Award in Medical and Population Genomics, 2010-2015.
  • Junior 1 Research Scholar, FRSQ, 2008-2011.
  • Faculty Research Award, Sigma Xi, North Carolina State University, USA, 2007.
  • Travelling Scholar, Wellcome Trust, 2001-2004.
  • Postdoctoral Fellowship, Natural Sciences and Engineering Research Council of Canada, 2001.
  • Postdoctoral Fellowship, Killam Trust, 2000

Most Important Publications Selected by the Researcher
Awadalla P, Boileau C, Payette Y, Idaghdour Y, Goulet J, Knoppers B, Hamet P, Laberge C, on behalf of the CARTaGENE Project,
Cohort profile of the CARTaGENE study: Quebec's population-based biobank for public health and personalized genomics
Int J Epidemiol 2013  1285-1299.
Hussin J, Sinnett D, Casals F, Idaghdour Y, Bruat V, Saillour V, Healy J, Grenier JC, de Malliard T, Busche S, Spinella JF, Larivière M, Gibson G, Andersson A, Holmfeldt L, Ma J, Wei L, Zhang J, Andelfinger G, Downing JR, Mullighan CG, Awadalla P,
Rare allelic forms of PRDM9 associated with childhood leukemogenesis
Genome Res 2013  419-430.
1000 Genomes Project Consortium, Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean G, Awadalla P,
An integrated map of genetic variation from 1,092 human genomes
Nature 2012  56-65.
Idaghdour Y, Quinlan J, Goulet J, Berghout J, Gbeha E, Bruat V, de Malliard T, Grenier JC, Gomez S, Gros P, Rahimy MC, Sanni A, Awadalla P,
Evidence for additive and interaction effects of host genotype and infection in malaria
Proc Natl Acad Sci USA 2012  16786-16793.
Conrad DF, Keebler J, DePristo MA, Lindsay SJ, Zhang Y, Casals F, Idaghdour Y, Hartl CL, Torroja C, Garimella KV, Zilversmit M, Cartwright R, Rouleau GA, Daly M, Stone EA, Hurles ME, Awadalla P, 1000 Genomes Project,
Variation in genome-wide mutation rates within and between human families
Nat Genet 2011  712-714.
Publications reported to FRSQ

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