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CHU Sainte-Justine
3175 Chemin de la Côte Sainte-Catherine
Montréal  (QC), Canada
H3T 1C5
514 345-4713
514 345-4897
Career Summary, Research Topics and Interests
  • Assistant Clinical Professor, Allergy-Immunology-Rheumatology Unit, Department of Pediatrics, University of Montreal.

  • Clinician Scientist, CHU Sainte-Justine Research Center.


  • PhD (Immunology), Pasteur Institute, Université Pierre et Marie Curie (UPMC), Paris, 2006-2010.

  • Master’s (Immunology), Faculty of Medicine, Necker Hospital for Sick Children, UPMC, Paris, 2004-2005.

  • Fellowship in Pediatric Immunology and Rheumatology, Necker Hospital for Sick Children, Paris, 2003-2005.

  • Specialized Studies Diploma in Pediatrics, University of Montreal, 1999-2003.

  • MD, McGill University, 1994-1999.

Research Interests

The ability to develop and maintain a population of memory cells after an infection or vaccination is the hallmark of adaptive responses and the basis of preventive vaccination against infectious pathogens. Understanding the mechanisms implicated in the differentiation of CD8+ T -lymphocytes is therefore essential for improving immunological memory after vaccination and developing novel cell-based therapies for the treatment of chronic viral infections and cancer. For this reason, our research interests focus, on the one hand, on the study of cell factors that are essential for eliminating a viral pathogen or a tumoral antigen and, on the other hand, on generating and maintaining antigen-specific memory CD8+ T -lymphocytes. By using transgenic mice, we are concentrating our efforts on the role of common gamma-chain dependent cytokines in the differentiation and generation of memory CD8+ T -lymphocytes after an viral infection or vaccination. We are also interested in the cytotoxic mechanisms that are essential for the effective elimination of viral or tumoral antigens, and on the development of T cell exhaustion in these contexts. Finally, we are interested in the kinetics of the reconstitution and function of CD8+ T -lymphocytes after bone marrow transplant.

Awards and Distinctions
  • Clinical Research Scholar Junior 1 Award, Fonds de Recherche en Santé du Québec (FRSQ), 2012-2016
  • Canadian Child Health Clinician Scientist Career Development Award (CCHCSP), 2011-2015
  • Cole Foundation Transition Award, 2011-2014
  • Research Award, Canadian Louis Pasteur Foundation, 2008-2010
  • Doctorate Award, Fonds de Recherche en Santé du Québec (FRSQ), 2008-2009
  • Canadian Institutes of Health Research (CIHR) Industry Partnered Award, 2006-2008
  • Junior Research Fellowship Award, Association de Recherche sur le Cancer, 2006
Most Important Publications Selected by the Researcher
Decaluwé H, Taillardet M, Corcuff E, Munitic I, Law HK, Rocha B, Rivière Y, Di Santo JP,
Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors
Proc Natl Acad Sci USA 2010  9311-9116.
Munitic I, Decaluwé H, Evaristo C, Lemos S, Wlodarczyk M, Worth A, Le Bon A, Selin LK, Rivière Y, Di Santo JP, Borrow P, Rocha B,
Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection
J Virol 2009  11795-11807.
Neven B, Leroy S, Decaluwé H, Le Deist F, Picard C, Moshous D, Mahlaoui N, Debre M, Casanova JL, Dal Cortivo L, Madec Y, Hacein-Bey-Abina S, de Saint Basile G, de Villartay JP, Blanche S, Cavazzana-Calvo M, Fischer A,
Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency
Blood 2009  4114-4124.
Rottman M, Soudais C, Vogt G, Renia L, Emile JF, Decaluwé H, Gaillard JL, Casanova JL,
IFN-gamma mediates the rejection of haematopoietic stem cells in IFN-gammaR1-deficient hosts
PLOS Medicine 2008  e26.
Masse GX, Corcuff E, Decaluwé H, Bommhardt U, Lantz O, Buer J, Di Santo JP,
Gamma(c) cytokines provide multiple homeostatic signals to naive CD4(+) T cells
Eur J Immunol 2007  2606-1616.
Publications reported to FRSQ

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