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SOUDEYNS , Hugo  PhD
 
 
     
 
Research Axis
 
   
 
 
 
Research Theme
 
   
 
 
 
Address
 
 
CHU Sainte-Justine
 
 
Centre de recherche
 
 
3175 Chemin de la Côte Sainte-Catherine
 
 
Montréal  (QC), Canada
 
 
H3T 1C5
 
     
 
Phone
 
 
514 345-4931 #3907
 
 
 
 
Fax
 
 
514 345-4801
 
     
     
     

hugo.soudeyns@recherche-ste-justine.qc.ca
 
 
Career Summary, Research Topics and Interests
 

Title

  • Associate Professor, Department of Microbiology and Immunology, University of Montreal.

Education

  • Posdoctorate, Microbiology, University of Lausanne, 1999.

  • PhD, Microbiology, University of Montreal, 1997.

Research Interests

Hugo Soudeyn trained in microbiology and immunology. He has been mostly active in three main areas of HIV/AIDS research.

The development and testing of antiretroviral drugs
This work, performed during my master's degree, led to the identification of lamivudine (3TC), a widely-prescribed antiretroviral compound.

The molecular genetics of HIV-1 gene expression
This work led to the identification of intragenic hormone response elements within the HIV-1 genome.

The study of host cell-mediated immune responses during acute and chronic HIV infection
We observed TCR chain-specific expansions of T cells during primary HIV infection (PI), and realized that these expanded cell populations comprised HIV-specific cytotoxic T lymphocytes (CTL). We discovered that some of these clones underwent clonal exhaustion during PI, studied the compartmentalization of HIV-specific CTL between lymph nodes and peripheral blood, identified molecular evidence for the selection of CTL escape mutants during PI, and defined the effects of antiretrovirals on the mobilization of CTL responses.

In collaboration with the CHU Sainte-Justine Centre maternel et infantile sur le sida, Dr Soudeyns has been involved in long-term efforts to characterize CTL responses in HIV-infected children. This work led to the identification of important differences in cell-mediated immunity between adults and children, and contributed to the understanding of the pathogenesis of paediatric HIV infection. In January 2000, Dr Soudeyns opened a research unit devoted to the study of viral immuno-pathology and childhood auto-immune diseases. His primary research interests now focus on mother-to-child transmission of hepatitis C virus (HCV), HCV-specific cell-mediated immunity during pregnancy and childhood, as well as T cell migration and targeting.

 
Awards and Distinctions
 
  • PhD thesis featured on the Dean's Honor List, McGill University, 1997.

  • New Investigator Award (Basic Science), Canadian Association for HIV Research, 1996.


 
Most Important Publications Selected by the Researcher
 
Ransy DG, Motorina A, Merindol N, Akouamba BS, Samson J, Lie Y, Napolitano LA, Lapointe N, Boucher M, Soudeyns H,
Evolution of HIV-1 coreceptor usage and coreceptor switching during pregnancy
AIDS Res Hum Retroviruses 2013  (sous presse).
 
   
Escobar-Gutiérrez A, Soudeyns H, Larouche A, Carpio-Pedroza JC, Martinez-Guarneros A, Vazquez-Chacon CA, Fonseca-Coronado S, Yamasaki LH, Ruiz-Tovar K, Cruz-Rivera M,
Vertical transmission of hepatitis C virus: a tale of multiple outcomes
Infect Genet Evol 2013  465-70.
 
   
Merindol N, Salem Fourati I, Brito RM, Grenier A, Charrier E, Cordeiro P, Caty M, Mezziani S, Malette B, Duval M, Alfieri C, Ovetchkine P, Le Deist F, Soudeyns H,
Reconstitution of protective immune responses against cytomegalovirus and varicella zoster virus does not require disease development in pediatric recipients of umbilical cord blood transplantation
J Immunol 2012  5016-5028.
 
   
Côté H, Soudeyns H, Thorne A, Alimenti A, Lamarre V, Maan EJ, Sattha B, Singer J, Lapointe N, Money DM, Forbes J, CIHR Emerging Team in HIV therapy, aging (CARMA), Wong J, Bitnun A, Samson L, Brophy J, Burdge D, Pick N, van Schalkwyk J, Montaner J, Harris M, Janssen P,
Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia
PLoS ONE 2012  e39266.
 
   
Larouche A, Gaëtan G, El-Bilali N, Quesnel-Vallières M, Martin S, Alvarez F, Shoukry NH, Soudeyns H,
Seronegative hepatitis C virus infection in a child infected via mother-to-child transmission
J Clin Microbiol 2012  2515-2519.
 
   
Publications reported to FRSQ
 
 
 
 
























 
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