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CHU Sainte-Justine
Centre de recherche
3175 Chemin de la Côte Sainte-Catherine
Montréal  (QC), Canada
H3T 1C5
514 345-4931 #6275
514 345-4801
Career Summary, Research Topics and Interests

The Pharmacokinetics Laboratory of the Department of Medical Biology studies the relationships that exist between concentrations of medications and their metabolites (medication transformation products) in plasma and blood cells, and therapeutic response, according to genetic characteristics of individuals or a given population (French Canadians, Amerindians, American Blacks, Asians). These characteristics (or polymorphisms) can translate into a deceleration or an acceleration in the enzymatic transformation of medication and/or an amplification or reduction in medicated response on specific tissue sites. By determining these various variables, it is possible to individualize and optimize therapeutic treatment while minimizing toxic effects.

Our studies with thiopurines (6-mercaptopuirine or Purinethol; azathioprine or Imuran) administered to children have made it possible to validate this axiom. Thus, patients with an activity deficiency of a particular transferase enzyme (thiopurine methyltransferase) have higher concentrations of active metabolites (nucleotides of 6-thioguanine) and a higher percentage of therapeutic response than patients who do not have reduced enzymatic activity. The sex and age of the patient are also determining factors when it comes to the pharmacokinetics of the medication and therapeutic response. Facing the obvious impracticality of performing pharmacokinetics (measuring the concentration of the medication and its metabolites per unit of time) on all drugs administered to children with various ailments, we also studies the possible relationships between the intensity of the drug dose (quantity administered per unit of time) and the therapeutic response as evaluated by various parameters (white blood cell count, gastric acidity, hepatic enzymes). Specialized software makes it possible to determine these relationships.

Most Important Publications Selected by the Researcher
Ansari M, Théorêt Y, Rezgui MA, Peters C, Mezziani S, Desjean C, Vachon MF, Champagne M, Duval M, Krajinovic M, Bittencourt H, Pediatric Disease Working Parties of the European Blood and Marrow Transplant Group,
Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematopoietic stem cell transplantation
Therap Drug Monit 2014  93-99.
Lapeyraque AL, Kassir N, Théorêt Y, Krajinovic M, Clermont MJ, Litalien C, Phan V,
Conversion from twice- to once-daily tacrolimus in pediatric kidney recipients: a pharmacokinetic and bioequivalence study
Pediatr Nephrol 2014  1081-1088.
Autmizguine J, Watt KM, Théorêt Y, Kassir N, Laferrière C, Parent S, Tapiero B, Ovetchkine P,
Pharmacokinetics and pharmacodynamics of oral cephalexin in children with osteoarticular infections
Pediatr Infect Dis J 2013  1340-1344.
Launay E, Théorêt Y, Litalien C, Duval M, Alvarez F, Lapeyraque AL, Phan V, Larocque D, Poirier N, Lamarre V, Ovetchkine P,
Pharmacokinetic profile of valganciclovir in pediatric transplant recipients
Pediatr Infect Dis J 2012  405-407.
Versace F, Uppugunduri CR, Krajinovic M, Théorêt Y, Gumy-Pause F, Mangin P, Staub C, Ansari M,
A novel method for quantification of sulfolane (a metabolite of busulfan) in plasma by gas chromatography-tandem mass spectrometry
Anal Bioanal Chem 2012  1831-1838.
Publications reported to FRSQ

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